Preimplantation Genetic Testing, PGT-M

What you need to know about PGT-M

Preimplantation genetic testing for monogenic diseases, or PGT-M, is a test that we can perform on IVF embryos. This test can identify which embryos have a specific genetic abnormality. This information allows couples to move forward confidently with embryo transfer. Transferring the healthiest embryos to the uterus increases the chances of having a successful pregnancy and delivering a healthy baby.

With this technique, an embryologist removes a few cells from each embryo and ships the samples to a reference genetics lab for testing. The lab then examines the chromosomes, looking for genes associated with a specific heritable disease. With this test, we can find cystic fibrosis, muscular dystrophy, Tay-Sachs, hemophilia, sickle cell disease and more.

Who should consider PGT-M?

The team at our Southern California fertility center recommends PGT-M for certain patients.

  • People diagnosed with a genetic disease
  • Carriers of a specific genetic abnormality
  • Those with a family history of a genetic or chromosomal disorder
  • People at risk for passing a genetic disease to their children

Our team is happy to work with patients to determine whether this type of testing is a good option to help them bring home a healthy baby.

Concerns about this type of testing

Some people may have religious or cultural beliefs that prevent them from using PGT-M. Others see it as a ray of hope as they near the end of their IVF journey.

This technique is a safe procedure, but no test can guarantee a 100% successful pregnancy or a healthy baby. Also, the embryo biopsy may cause minimal damage to the embryo. This is rare, but it can occur.

For many, the potential benefits far outweigh these risks because they are concerned about bringing a child into this world who could suffer from a lifelong medical condition. Many hopeful parents appreciate the chance to break the vicious cycle of passing down inherited diseases to their children. No matter what your beliefs or circumstances are, the decision is always yours. Our Southern California fertility center will support you every step of the way.

Contact us to learn more about IVF and PGT-M at our Southern California fertility center.