Mitchel C. Schiewe, Biographical Sketch

• Our Fertility Care Staff
  • About Our Fertility Specialists
  • Robert E. Anderson, MD
  • N. Edward Dourron, MD
  • Sharon E. Moayeri, MD
  • Grace Pak, D.C., L.Ac., M.S., QME
  • Mitchel Schiewe Ph.D.
• Our Fertility Laboratory - The Southern California Institute for Reproductive Sciences
• About Our IVF Success Rates
• The Importance of Individualized Care
• IVF Success Stories and Patient Testimonials
• IVF Cost at Southern California Center for Reproductive Medicine
• IVF Cost Information
• Our Office Hours
• Fertility Treatment Insurance Information

Education

Post-doc

NRC Research Associate, National Institutes of Health, 1/90-12/91 Bethesda, Maryland

Ph.D. program

Physiology, Uniformed Services University, 8/84-12/89 of the Health Sciences
Bethesda, Maryland

M.S. program

Animal Science Louisiana State University, 8/81-5/83 Baton Rouge, Louisiana

Undergraduate

Animal Science, University of California, 9/76-6/81 Davis, California

Academic Appointments

• 1/95-5/99 Guest Clinical Professor, University of California, Irvine, CA
• 4/93-1/95 Assistant Professor In-Residence, University of California, Irvine, CA
• 1/92-4/93 Assistant Researcher, University of California, Irvine, CA
• 8/81-5/83 Research/Teaching Assistant, Louisiana State University, Baton Rouge, LA
• 8/84-12/89 Research/Teaching Assistant, Uniformed Services University, Bethesda, MD

Non-Academic Appointments

• 11/99-present Scientific Director of Embryology, Fertility & Surgical Assoc., Thousand Oaks, CA
• 11/94-6/00 Guest Scientist, Studio Interdisciplinare Fecondazione e Transfer, Rome, Italy
• 3/90-1/00 Research Associate, Smithsonian Institution, Washington, DC
• 1/95-5/99 Director, IVF & Embryology, California Fertility Associates, Santa Monica, CA
• 6/92-1/95 Guest Scientist, Beckman Laser Institute, UCI, Irvine, CA
• 9/94-1/95 Director, Micromanipulation & Experimental Embryology, Center for
  Reproductive Health, UCI, Irvine, CA
• 1/90-12/91 National Research Council Associateship, Veterinary Resources Program, Embryo Cryopreservation Program, National Institutes of Health, Bethesda, MD
• 9/87-12/89 Guest Scientist, Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Fredrick, MD
• 8/84-12/89 Research Fellow, National Zoological Park, Smithsonian Institution
• 7/83-7/84 Research Intern, Reproductive Physiology Program, National
  Zoological Park, Smithsonian Institution, Washington, DC
• 8/83-12/89 Guest Scientist, Veterinary Resources Branch, National Institutes of Health, Bethesda, MD

Professional Activity

Board Certification

12/94 Laboratory Supervisor/Consultant (TS-1995, HCLD-1996-present, ELD-2003), American Board of Bioanalysts, St. Louis, MO

Service to Professional Societies

1990-present Ad Hoc Journal Reviewer, Theriogenology and Fertility & Sterility

1990-2004 Periodic Abstract Reviewer, IETS and ASRM

2001/2004 ASRM Moderator, ART and RBPG sessions

1/90-1/00 Import/Export Committee and Research Subcommittee, International Embryo Transfer Society.

1/92-1/98 Board of Trustees (Vice-Chairman, 1993; Chairman, 1994-97) and Education Committee (Chairman, 1992-1996), International Embryo Transfer Society Fdn.

1990,1995 Invited Speaker, IETS Annual Meeting

1/86-1/92 Placement Service Organizer, International Embryo Transfer
Society Annual Meetings

1/88-1/00 Manual Revision Group, International Embryo Transfer Society

Grants

* Received Funding on four major research grants ($21,500 to $150,000 each; 1988-1994)

Publications

*35 peer-reviewed papers and 70 abstracts presented at national and international meetings. See CV for complete list.

Journal Articles (examples)
1. Schiewe, MC, M Bush, LD Stuart and DE Wildt. Laparoscopic embryo transfer in domestic sheep: A preliminary study. Theriogenology 22:675-682, 1984.

2. Schiewe, MC, PM Schmidt, M Bush and DE Wildt. Toxicity potential of absorbed/retained ethylene oxide residues in culture dishes on embryo development in vitro. J Anim Sci 60:1610-1618, 1985.

10. Schiewe, MC, PM Schmidt, DE Wildt and WF Rall. Quality control measures in an embryo research programs. Theriogenology 33:9-22, 1990.

14. Schiewe, MC The science and significance of embryo cryopreservation. J Zoo Wildlf Med 22:6-22, 1991.

16. Schiewe, MC, WF Rall, LD Stuart and DE Wildt. Ovine embryo cryopreservation: Analysis of cryoprotectant, cooling rate and in situ straw dilution using conventional freezing or vitrification. Theriogenology 36:279-293, 1991.

17. Schiewe, MC, CT Hansen and PM Schmidt. Lack of antibody specificity by
mouse trophectoderm during immunosurgery. Theriogenology.38: 21-32, 1992.

21. Schiewe, MC, NL Hazeleger, C Sclimenti and JP Balmaceda. Physiological
characterization of blastocyst hatching mechanisms by use of a mouse anti-hatching model. Fertil Steril 63: 288-294, 1995.

22. Schiewe, M.C., E. Araujo Jr., R.H. Asch and J.P. Balmaceda. Enzymatic characterization of zona pellucida hardening in human eggs and embryos. J. Asst. Reprod. Genet. 1995, 12:2-7.

24. Schiewe, MC, Y Neev, N Hazeleger, Y Tadir, MW Berrns and J Balmaceda. Developmental competence of mouse embryos following zona drilling using a non-contact Ho:YSSG laser system. Hum Reprod 1995, 10:101-105.

25. Rojas, FJ, C Garner, M Schiewe, RH Asch, JP Balmaceda and I Moretti-Rojas. Enzymatic amplification of specific deoxyribonucleic acid sequences from single cells: evaluation of a simplified and rapid method for use in preimplantation genetic diagnosis. Fertil. Steril. 1995; 64:255-260.

26. Gook, D, MC Schiewe, SM Osborn, RH Asch , RPS Jansen and WIH Johnston. Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1,2-propanediol. Hum Reprod 1995; 10:2637-2641.

27. Schiewe, MC. An effective, simplified and practical approach to intracytoplasmic sperm injection at multiple IVF Centers. J Asst Reprod Genet 1996; 13:238-245.

Recent Clinical Abstracts

Schiewe, MC, GD Hubert and RP Buyalos. Human zygote cryopreservation using CBS cryobiostraws: A randomized clinical study. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl. 3), 77:S22, 2002.

Schiewe, MC, GD Hubert and RP Buyalos. Testicular tissue processing: Maximizing viability for cryopreservation and clinical use. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3), 81:S15; O-13, 2004.

Schiewe, MC, GD Hubert and RP Buyalos. Poor fertility predictive value of the sperm chromatin structure assay (SCSA) is neutralized by sperm injection: Case studies. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3), 81:S27-27; P-32, 2004.

Schiewe, MC, GD Hubert and RP Buyalos. Use of CBSTM high security straws for conventional freezing of human blastocysts. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3); P-58, 2005.

Schiewe, MC, GD Hubert and RP Buyalos. Pre-freeze manual collapsing of the blastocoel cavity increases cryosurvival of human blastocysts. Proc. 61st Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl 1), 84:S182, 2005.

Proposed Program Idea

Using my experience in the Washington, DC area to recruit some local speakers and my diverse background in Comparative Physiology and Embryo Technologies, I believe a post-graduate program emphasizing a “Historical Perspective on the Development and Use of ART in Animal Research, Human IVF and Wildlife Conservation: Who has Benefited from Who?” would be an interesting topic to multiple disciplines/interest groups in ASRM. The latter program will be both entertaining and highly educational, especially to young biologists and other professionals lacking the historical knowledge of how different ARTs developed and have been utilized.