Southern California Fertility IVF Laboratory in Los Angeles.

Mitchel C. Schiewe, M.S., Ph.D., HCLD (ABB), ELD (ABB), Laboratory Director

View Mitchel Schieve's Bio graphical Sketch

Back to Embryology Laboratory Staff

Lab Director at Southern California Center for Reproductive Medicine

CURRICULUM VITAE

Education

Post-doc

NRC Research Associate, National Institutes of Health, 1/90-12/91 Bethesda, Maryland

Ph.D. program

Physiology, Uniformed Services University, 8/84-12/89 of the Health Sciences
Bethesda, Maryland

M.S. program

Animal Science Louisiana State University, 8/81-5/83 Baton Rouge, Louisiana

Undergraduate

Animal Science, University of California, 9/76-6/81 Davis, California

Languages

English Fluent speaking, reading, writing
Spanish, Italian Basic words and phases

Academic Appointments

  • 1/95-5/99 Guest Clinical Professor, University of California, Irvine, CA
  • 4/93-1/95 Assistant Professor In-Residence, University of California, Irvine, CA
  • 1/92-4/93 Assistant Researcher, University of California, Irvine, CA
  • 8/81-5/83 Research/Teaching Assistant, Louisiana State University, Baton Rouge, LA
  • 8/84-12/89 Research/Teaching Assistant, Uniformed Services University, Bethesda, MD

Non-Academic Appointments

  • 11/99-present Scientific Director of Embryology, Fertility & Surgical Assoc., Thousand Oaks, CA
  • 11/94-6/00 Guest Scientist, Studio Interdisciplinare Fecondazione e Transfer, Rome, Italy
  • 3/90-1/00 Research Associate, Smithsonian Institution, Washington, DC
  • 1/95-5/99 Director, IVF & Embryology, California Fertility Associates, Santa Monica, CA
  • 6/92-1/95 Guest Scientist, Beckman Laser Institute, UCI, Irvine, CA
  • 9/94-1/95 Director, Micromanipulation & Experimental Embryology, Center for
    Reproductive Health, UCI, Irvine, CA
  • 1/90-12/91 National Research Council Associateship, Veterinary Resources Program, Embryo Cryopreservation Program, National Institutes of Health, Bethesda, MD
  • 9/87-12/89 Guest Scientist, Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, Fredrick, MD
  • 8/84-12/89 Research Fellow, National Zoological Park, Smithsonian Institution
  • 7/83-7/84 Research Intern, Reproductive Physiology Program, National
    Zoological Park, Smithsonian Institution, Washington, DC
  • 8/83-12/89 Guest Scientist, Veterinary Resources Branch, National Institutes of Health, Bethesda, MD


Professional Activity

Board Certification

12/94 Laboratory Supervisor/Consultant (TS-1995, HCLD-1996-present, ELD-2003), American Board of Bioanalysts, St. Louis, MO

Honors

  • 5/99 Outstanding Graduate Alumus Award (1st recipient: “Troy T. Beeler Award” for Outstanding International Contributions in Research), Uniformed Services University of the Health Sciences, Bethesda, MD
  • 4/99 Runner-up Award, TAP Poster Award for scientific contribution, Pacific Coast Reproductive Society, 47th annual conference, Carlsbad, CA
  • 10/89-12/91 National Research Council Associate Fellowship, National Institutes of Health
  • 5/90 Commencement Speaker, Uniformed Services University at the Kennedy
    Center, Washington, D.C.
  • 10/89 First Place Award, Student Research Competition, American Association of Zoo Veterinarians Annual Meeting, Greensboro, NC
  • 5/88 Emma Bockman Memorial Award for Outstanding Graduate Research and Teaching, Uniformed Services University
  • 1/85 First Place Award (Co-author/PI), Student Research Competition,
    International Embryo Transfer Society Annual Meeting, Montreal, Canada
  • 1/84 First Place Award and Travel Grant Award, Student Research Competition, International Embryo Transfer Society Annual Meeting, San Antonio,TX
  • 1/83 Runner-up Award, Student Research Competition, International Embryo Transfer Society Annual Meeting, Ft. Collins, CO
  • 5/83 Honorary Academic Fraternity, Gamma Sigma Delta
  • 6/82-5/83 Graduate Student Representative, Department of Animal Science, Louisiana State University, Baton Rouge, LA
  • 6/81 Commencement Speaker, College of Agriculture and Environmental Sciences, University of California, Davis, CA
  • 6/81 Outstanding Leadership Award, Department of Animal Science and for the College of Agricultural and Environmental Sciences, University of California, Davis, CA
  • 6/80-6/81 Dean's Student Advisor, College of Agricultural and Environmental Sciences, University of California, Davis, CA
  • 1/80-12/80 Intercollegiate Livestock Judging Team (numerous awards), University of California, Davis, CA

Grants and Awards

  • 1/92-1/93 Memorial Health Services grant ($21,350), Principal Investigator, project title: Maturation of Follicular Oocytes Recovered from the Non-Hormonally Stimulated Ovaries of Women Diagnosed with Cancer
  • 1/92-1/94 Memorial Health Services grant (Yr.1: $28,000, Yr.2: $33,000), Co-Principal Investigator with Dr. Jose P. Balmaceda, project title: Biophysical and Chemical Characterization of Zona Pellucida Hardening Associated with In Vitro Embryo Culturing, and its Functional Relationship to Implantation

    8/90-8/95 USAID/PSTC grant ($150,000), Biodiversity section, Co-Principal Investigator with Dr. David E. Wildt, project title: Enhancement of Cattle Productivity While Conserving Wild Cattle Species Indigenous to Southeast Asia
  • 12/88 Research Opportunity Fund Award ($2,500) to travel to and finalize conservation biology grant in Thailand and Malaysia, Smithsonian Institution
  • 4/88 Research Opportunity Fund Award ($2,500) to travel to Thailand and Malaysia, Smithsonian Institution

Invited Presentations

  • 10/06 Inside the IVF Laboratory, RESOLVE Ann.Mtg, LA County, UCLA campus.
  • 7/98 Basic Embryology and Applied/Experimental Micromanipulation in Human IVF, Asst. Reprod. Techology 1998, Santa Monica-UCLA Med. Ctr., Santa Monica, CA
  • 12/97 Experimental Aspects of Assisted Fertilization, Serono Symposium “ART: State of the Art,” Maui HA (Invited Speaker)
  • 9/95 ICSI and Assisted Hatching of Human Gametes and Embryos, Santa Monica Hospital Medical Center Symposia, Santa Barbara, CA (Invited Speaker)
  • 7/95 Micromanipulation of Human Gametes and Embryos, Santa Monica Hospital Medical Center Symposia,, Santa Monica, CA (Invited Speaker)
  • 5/95 ICSI Debate: The Con Side of When and How to Apply ICSI and/or Assisted Hatching. Serono conference for the New Jersey Embryology Society, Newark, NJ (Invited Speaker)
  • 1/95 Laser Zona Drilling to Assist Hatching and a Look at Why Assisted Hatching May be Necessary. OB/GYN Grand Rounds, University of California-Irvine Medical Center, Orange, CA (Invited Speaker)
  • 9/94 Oocyte Rescue: Preserving a Womens' Reproductive Capacity. OB/GYN Grand Rounds, University of California-Irvine Medical Center, Orange, CA (Invited Speaker)
  • 6/94 Characterization of blastocyst anti-hatching mechanisms: Why is assisted hatching necessary? University of Hawaii at Manoa, Oahu, HA (Invited speaker)
  • 6/94 Reproductive management of captive and free-ranging wildlife, and the future possibility of germplasm cryobanking and species reintroduction, Biology 65 Course, University of California, Irvine, CA (Guest lecturer)
  • 3/94 Micromanipulation of Gametes and Embryos:Animal Model to Human Application, Endocrinology & Infertility Conference, Saint Joseph Hospital, Orange, CA (CME lecture).
  • 9/93 Animal Modeling in the Advancement of Reproductive Technologiesfor Biomedical and Conservation Applications, Tri-Branch ALAS Conference, Calif. State Polytech University, Pomona, CA (Invited speaker)
  • 9/93 Micromanipulation of Human Gametes and Embryos, OB/GYN Grand Rounds, University of California-Irvine Medical Center, Orange, CA (Invited speaker)
  • 6/93 Reproductive management of captive and free-ranging wildlife, and the future possibility of germplasm cryobanking and species reintroduction, Biology 65 Course, University of California, Irvine, CA (Guest lecturer)
  • 5/93 Micromanipulation of human gametes and embryos, Endocrinology & Infertility Conference, Saint Joseph Hospital, Orange, CA (CME Lecture).
  • 4/93 Micromanipulation of mammalian embryos: Past, present and future, Department of Developmental & Cell Biology, University of California, Irvine, CA (Invited speaker)
  • 2/93 Use of animal models for embryo technology research, American Lab Animal Society (ALAS) Palms-to-Pines Branch, Irvine, CA. (Guest speaker)
  • 7/92 Development and funding of an international conservation biology program, Animal Biodiversity Conservation Course, UC Davis (Lecturer).
  • 7/92 Determining and understanding the reproductive physiology of wild cattle species indigenous to southeast Asia, Animal Biodiversity Conservation Course, UC Davis (Lecturer).
  • 7/91 Blastocyst reconstitution: An experimental tool for successful interspecific embryo transfer, National Zoological Park (Guest speaker).
  • 6/91 Experimental reconstitution of embryonic trophectoderm and inner cell mass: An approach for improving intraspecies, interspecies and intergeneric embryo transfer, Veterinary Resources Program, National Institutes of Health (Guest speaker).
  • 6/91 Species variations in semen cryopreservation, Wild Cattle Symposium, Henry Doorly Zoo, Omaha, NE (Guest speaker).
  • 3/91 Gamete interactions, fertilization and assisted fertility, Reproductive Physiology Course, Uniformed Services University (Lecturer).
  • 3/91 Embryology and embryo micromanipulation, Reproductive Physiology Course, Uniformed Services University (Lecturer).
  • 9/90 Laparoscopy in sheep: A tool for artificial breeding, VA-MD Regional College of Veterinary Medicine Workshop, College Park, MD (Lecturer/Demonstrator).
  • 4/90 Use of artificial techniques to control and enhance reproduction in nondomestic species, Zoo Biology Course, University of Maryland (Lecturer).
  • 3/90 Application of reproductive biotechniques in conservation biology, Conservation Biodiversity Group, National Zoological Park (Guest speaker).
  • 10/89 Biodiversity research: The use of embryo and semen cryopreservation techniques for the preservation and potential commercial utility of wild cattle species indigenous to Southeast Asia, National Zoological Park (Guest speaker).
  • 4/88 Application of advanced reproductive technologies in wildlife species, Zoological Park Organization Board of Directors, Bangkok, Thailand (Guest speaker).
  • 5/87 Semen characteristics, sperm freezing and endocrine profiles in free-ranging wildebeest and greater kudu, VII Graduate Student Colloquium, Uniformed Services University (Student speaker).
  • 5/86 Reproductive physiology research at the National Zoological Park, Miami-Metro Zoo, Miami, FL (Guest speaker).
  • 5/86 Influence of cryoprotectant and plunge temperature on the post-thaw viability of ovine embryos, VI Graduate Student Colloquium, Uniformed Services University (Student speaker).
  • 4/86 Potential application of mammalian embryo micromanipulation for the preservation of endangered nondomestic species, Course, Advances in Reproductive Biology of Wildlife Species, National Zoological Park (Lecturer).
  • 10/85 Reproductive Physiology Research at the National Zoo, Friends of the National Zoo (FONZ) Board of Directors (Guest speaker).
  • 4/85 Micromanipulation of mammalian embryos, National Cancer Institute, Section of Genetics (Guest speaker).

 

Oral Presentations at Professional Meetings

  • 4/04 Testicular Tissue Processing: Maximizing Viability For Cryopreservation And Clinical Use. Proc. Pacific Coast Reprod. Soc. Mtg, Rancho Mirage, CA.
  • 4/99 Single Sperm Freezing in Evacuated Mouse Zona Pellucida: Comparative Trial on Zona Preparation and Sperm Isolation Procedures, Proc. Pacific Coast Reprod. Soc. Mtg, Carlsbad, CA.
  • 4/99 Murine Embryo Growth in Different Culture Media and Sequential Combinations: A Model for Application to Human IVF, Proc. Pacific Coast Reprod. Soc. Mtg, Carlsbad, CA.
  • 10/98 Comparative development of ICSI-derived human embryos in HTF, P-1, QB-XI and D3 media solutions. Proc. 54th Ann. Amer. Soc. Reprod. Med. Mtg., San Francisco, CA
  • 4/97 Production and Use of Zona Pellucida-Intact Mouse Trophectodermal Vesicles for Placental Donation, 45th Ann Pacific Coast Fertility Society Mtg, Palm Springs, CA
  • 4/96 Selective assisted hatching is beneficial but not mandatory for ICSI-derived embryos, Proc. 44th Ann. Pacific Coast Fertil Soc. Mtg., Palm Springs, CA (Invited speaker)
  • 1/96 Use of ICSI and selective assisted hatching in human assisted reproduction, International Embryo Transfer Society, Salt Lake City, UT (Invited Speaker)
  • 10/95 Embryo importation and cryopreservation strategies for laboratory animals and wildlife species, USAHA conference, Reno, NV (Invited Speaker)
  • 1/95 Embryo importation and cryopreservation strategies for laboratory animals and wildlife species, International Embryo Transfer Society, Calgary, Canada (Invited Speaker)
  • 4/94 Characterizing the mouse blastocyst anti-hatching model: Influence of initial developmental stage and late serum supplementation, Pacific Coast Fertility Society Conference, Palm Springs, CA (Invited Speaker)
  • 1/94 Application of assisted reproductive technologies in nondomestic species, Round Table Symposium at the International Embryo Transfer Society Meeting, Melbourne, Australia
  • 10/93 Enzymatic Characterization of Zona Pellucida Hardening in Human Eggs and Embryos, American Fertility Society Conference, Montreal, Ouebec, Canada (Invited Speaker)
  • 10/90 The domestic sheep: A research model for developing and applying advanced reproductive techniques to wildlife species, National Capital Area Branch/American Laboratory Animal Association Annual Meeting, Baltimore, MD (Invited speaker)
  • 1/90 Quality control measures in an embryo research program, International Embryo Transfer Society Annual Meeting, Denver, CO (Invited speaker)
  • 10/89 Post-thaw viability and acrosomal integrity of gaur (Bos gaurus) sperm following comparative cryopreservation, American Association of Zoo Veterinarians Annual Meeting, Greensboro, NC (Student research Competitor).
  • 7/87 Semen characteristics, sperm freezing and endocrine profiles in free-ranging wildebeest and greater kudu, XX Society for the Study of Reproduction Annual Meeting, Urbana, IL (Invited speaker).
  • 1/84 Effect of absorbed/retained ethylene oxide in plastic culture dishes on embryo development in vitro, International Embryo Transfer Society
    San Antonio, TX (Student research competitor).
  • 1/83 Transferrable embryo recovery rates following different artificial insemination schedules in beef donor cattle, International Embryo Transfer Society Annual Meeting, Ft. Collins, CO (Student research competitor).


Service to Professional Societies

  • 4/06-date Program Chairman 2007, ASRM, Reproductive Biologists Professional Group
  • 1/90-1/00 Import/Export Committee and Research Subcommittee, International Embryo Transfer Society.
  • 1/92-1/98 Board of Trustees (Vice-Chairman, 1993; Chairman, 1994-97) and Education Committee (Chairman, 1992-1996), International Embryo Transfer Society Fdn.
  • 1/86-1/92 Placement Service Organizer, International Embryo Transfer
    Society Annual Meetings
  • 1/88-1/00 Manual Revision Group, International Embryo Transfer Society

Service as Reviewer of Manuscripts and Referee of Proposals

  • Fertility and Sterility (1998 to present)
  • Theriogenology (1987 to present)
  • Journal of Zoo and Wildlife Medicine (10/90 to1995)
  • American Journal of Obstetrics & Gynecology (12/92 to 1/95)
  • Biology of Reproduction (8/92 to 1/95)
  • Smithsonian Institution, Scholarly Studies Grants (11/91 - present)
  • US Agency for International Development, PSTC-Biotechnology grants (8/87 to 10/87)

Membership in Professional Organizations

  • Alpha (International Society for Embryologists)
  • American Society for Reproductive Medicine
  • International Embryo Transfer Society
  • Pacific Coast Reproductive Society
  • American Association of Bioanalysts

Other Special Qualifications/Experiences

NIH Course: The Care and Use of Laboratory Animals (March 1990)
NIH Course: Radiation Safety Training for Authorized User’s (September 1990)

University and Public Service

Institution

NSF Workshop on “Research priorities for single species conservation biology,” conference assistant, Smithsonian Institution/National Zoological Park (November 1988)

Campus

Academic Senate (April 1993 to December 1994)
Interview Committee, College of Medicine (September 1993 to December 1994)
Animal Research Committee (June 1994 to December 1994)

Department

Committee on Research (March 1992 to December 1994)
Clinical Service: Micromanipulation of Severe Male Factor Infertility Cases

Community

RESOLVE Lecture: Behind the Scenes of an IVF Lab Applying Advanced Technologies, Westwood, CA, May 1998

Infertility Seminar Series, Santa Monica-UCLA Med. Ctr. (2 to 3 lectures/year, 1995-99)

  • “Micromanipulation of Human Gametes and Embryos”
  • “Assisted Fertilization: Sperm Injection (ICSI)”
  • “Assisted Hatching: Who needs it and why?
  • “Embryo Biopsy for Preimplantation Genetic Diagnosis”

National Association of Scientific Writers, Washington, DC chapter, participant in demonstration/presentation on “Various aspects of reproductive research at the National Zoo” (October 1989)

Metropolitan teachers of the Washington, DC area, Panel presentation on the“Conservation of wildlife: reproductive viewpoint” (August 1988)

Kerrin Terrier Society, Northern Virginia chapter, guest speaker (April 1985)

Southeastern Louisiana County Fair, livestock judge (February 1983)

Bulldog Society, Baton Rouge chapter, guest speaker (June 1982)

Dixon May Fair, Intercollegiate Livestock Judging Contest, co-coordinator (May 1981)


Publications
Book Chapters, (peer reviewed)

1. Schiewe, MC. Quality control measures for handling of embryos. In: Stringfellow, DA and Seidel, SM (eds.) Manual of the International Embryo Transfer Society: A Procedural Guide and General Information for the Use of Embryo Transfer Technology, Emphasizing Sanitary Precautions (2nd Ed.). International Embryo Transfer Society, Champaign, IL, 1990,
pp. 50-59.

2. Schiewe, MC. General hygiene and quality control practices in an embryo-production laboratory. In: Stringfellow,DA and Seidel, SM (eds.) Manual of the International Embryo Transfer Society: A ProceduralGuide and General Information for the Use of Embryo Transfer Technology, EmphasizingSanitary Precautions (3rd Ed.). International Embryo Transfer Society, Champaign, IL, pp. 93-102, 1998.

3. Schiewe, MC. Experimental Aspects of Assisted Fertilization. In: Marrs, RP, Rosenwaks, Z and Trounson, A (eds.) Assisted Reproductive Technologies: State-of-the-Art. Serono Symposia, Inc, NJ, 1998.

Journal Articles (peer-reviewed)

1. Schiewe, MC, M Bush, LD Stuart and DE Wildt. Laparoscopic embryo transfer in domestic sheep: A preliminary study. Theriogenology 22:675-682, 1984.

2. Schiewe, MC, PM Schmidt, M Bush and DE Wildt. Toxicity potential of absorbed/retained ethylene oxide residues in culture dishes on embryo development in vitro. J Anim Sci 60:1610-1618, 1985.

3. Wildt, DE, MC Schiewe, PM Schmidt, KL Goodrowe, JG Howard, LG Phillips,
SJ O'Brien and M Bush. Developing animal model systems for embryo technologies in rare and endangered wildlife. Theriogenology 25:33-51, 1986.

4. Howard, JG, M Bush, V de Vos, MC Schiewe, VG Pursel and DE Wildt. Influence of cryoprotective diluent on post-thaw viability and acrosomal integrity of spermatozoa of the African elephant (Loxodonta africana). J Reprod Fertil 78:295-306, 1986.

5. Schiewe, MC, PM Schmidt and DE Wildt. A comparative study of mouse embryo freeze-preservation including the examination of a thermoelectric freezing device. Cryobiology 24:238-246, 1987.

6. Schiewe, MC, CR Looney, CA Johnson, KG Hill and RA Godke. Transferrable embryo recovery rates following different insemination schedules in superovulated beef cattle. Theriogenology 28:395-406, 1987.

7. Schmidt, PM, MC Schiewe and DE Wildt. The genotypic responses of mouse embryos to multiple freeze variables. Biol Reprod 37:1121-1128, 1987.

8. Schiewe, MC, PM Schmidt, D Pontbriand and DE Wildt. Toxicity potential of residual ethylene oxide on embryos cryopreserved in gas-sterilized plastic straws. Gamete Res 19:31-39, 1988.

9. Pontbriand, D, JG Howard, MC Schiewe, LD Stuart and DE Wildt. Influence of freezing method and cryoprotective diluent on post-thaw survival and acrosomal integrity of ram spermatozoa. Cryobiology 26:341-354, 1989.

10. Schiewe, MC, PM Schmidt, DE Wildt and WF Rall. Quality control measures in an embryo research programs. Theriogenology 33:9-22, 1990.

11. Schiewe, MC, JG Howard, KL Goodrowe, LD Stuart and DE Wildt. Human menopausal gonadotropin (hMG) induces ovulation effectively in sheep, but embryo recovery after hMG, PMSG and FSH-P is compromised by premature luteal regression. Theriogenology 34:469-486, 1990.

12. Schiewe, MC, M Bush, LG Phillips, S Citino and DE Wildt. Comparative aspects of estrous synchronization, ovulation induction and embryo cryopreservation in the scimitar-horned oryx, bongo, eland and greater kudu. J Exp Zool 58:75-88, 1991.

13. Schiewe, MC, M Bush, V de Vos and DE Wildt. Semen characteristics, sperm freezing and endocrine profiles in free-ranging wildebeest (Connochaetes taurinus) and greater kudu (Tragelaphus strepsiceros). J Zoo Wildlf Med 22:58-72, 1991.

14. Schiewe, MC The science and significance of embryo cryopreservation. J Zoo Wildlf Med 22:6-22, 1991.

15. Schiewe, MC, TA Fitz, JL Brown, LD Stuart and DE Wildt. Relationship to
estrous synchronization, circulating hormones, luteinizing hormone/prostaglandin F2a receptors and luteal progesterone content to premature luteal regression in superovulated sheep. J Reprod Fert 93:19-30, 1991.

16. Schiewe, MC, WF Rall, LD Stuart and DE Wildt. Ovine embryo cryopreservation: Analysis of cryoprotectant, cooling rate and in situ straw dilution using conventional freezing or vitrification. Theriogenology 36:279-293, 1991.

17. Schiewe, MC, CT Hansen and PM Schmidt. Lack of antibody specificity by
mouse trophectoderm during immunosurgery. Theriogenology.38: 21-32, 1992.

18. Monfort, SL, GW Asher, DE Wildt, TC Wood, MC Schiewe, LR Williamson, M Bush and WF Rall. Successful intrauterine insemination in Eld's deer (Cervus eldi thamin) using frozen-thawed spermatozoa. J Reprod Fert 99: 459-465, 1993.

19. Schiewe, MC, V Hollifield LA Kasbohm and PM Schmidt. Embryo Importation and cryobanking strategies of laboratory animals and wildlife. Theriogenology 43: 97-104, 1995.

20. Loskutoff, NM, P Bartels, M Meintjes, RA Godke and MC Schiewe. Assisted reproductive technologies in nondomestic ungulates: a model approach to preserving and managing genetic diversity. Theriogenology 43: 3-12, 1995.

21. Schiewe, MC, NL Hazeleger, C Sclimenti and JP Balmaceda. Physiological
characterization of blastocyst hatching mechanisms by use of a mouse anti-hatching model. Fertil Steril 63: 288-294, 1995.

22. Schiewe, M.C., E. Araujo Jr., R.H. Asch and J.P. Balmaceda. Enzymatic characterization of zona pellucida hardening in human eggs and embryos. J. Asst. Reprod. Genet. 1995, 12:2-7.

23. Neev, Y, MC Schiewe, V Sung, D Kang, Y Tadir and M Berns. Assisted hatching using a non-contact Ho:YSGG laser system. J. Asst. Reprod. Genet. 12:288-293, 1995.

24. Schiewe, MC, Y Neev, N Hazeleger, Y Tadir, MW Berrns and J Balmaceda. Developmental competence pf mouse embryos following zona drilling using a non-contact Ho:YSSG laser system. Hum Reprod 1995, 10:101-105.

25. Rojas, FJ, C Garner, M Schiewe, RH Asch, JP Balmaceda and I Moretti-Rojas. Enzymatic amplification of specific deoxyribonucleic acid sequences from single cells: evaluation of a simplified and rapid method for use in preimplantation genetic diagnosis. Fertil. Steril. 1995; 64:255-260.

26. Gook, D, MC Schiewe, SM Osborn, RH Asch , RPS Jansen and WIH Johnston. Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1,2-propanediol. Hum Reprod 1995; 10:2637-2641.

27. Schiewe, MC. An effective, simplified and practical approach to intracytoplasmic sperm injection at multiple IVF Centers. J Asst Reprod Genet 1996; 13:238-245.

Proceedings Papers

1. Schiewe, MC, PM Schmidt, M Bush and DE Wildt. Effect of ethylene oxide
(EtO) on embryo development in vitro. Presented to the X International Congress of Animal Reproduction & AI, Champaign, IL, Vol. 2:237a-c, 1984.

2. Schmidt, PM, MC Schiewe, CT Hansen and DE Wildt. Technological considerations for freezing mammalian embryos. Presented to the 1st International Conference on Zoological and Avian Medicine, Oahu, HI, pp. 384-386, 1987.

3. Schiewe, MC, M. Bush, LP Phillips and DE Wildt. Variables influencing the collection and cryopreservation of embryos from nondomestic ungulate species. Presented to the X International Congress of Animal Reproduction & AI, Dublin, Ireland, Vol. 2:190a-c, 1988.

4. Howard, JG, BL Raphael, JL Brown, S Citino, MC Schiewe and M Bush. Male sterility associated with karyotypic hybridization in Kirk’s Dik-Dik. Presented to the American Association of Zoo Veterinarians, Greensboro, NC, pp. 58-60, 1989.

5. Schiewe, MC, S Junior, DL Armstrong, TS Gross, L Simmons, S Hopkins and DE Wildt. Post-thaw viability and acrosomal integrity of gaur (Bos gaurus) sperm following comparative cryopreservation. Presented to the American Association of Zoo Veterinarians, Greensboro, NC, pp. 62-65, 1989. (Outstanding Student Research Award)

6. Schiewe, MC. Species variation in semen cryopreservation of nondomestic ungulates. Presented at the Wild Cattle Symposium, Omaha, NE, pp. 56-64, 1991.

7. Loskutoff, NM, BL Raphael, BA Wolfe, LAN French, RB Buice, JG Howard,
MC Schiewe and DC Kraemer. Embryo transfer in small antelope. Presented to the Society for the Study of Theriogenology, San Diego, CA, pp. 341-342, 1991.

8. Santuari, E, A Ortensi, M Amodei, C Barbieri, V Marchese, A Massacesi, M Schiewe, P Giovenco, G. Custo and R Asch. Gravidaniza ottenuta con FIVET combinata con ICSI utilizzando spermatozoi epididimari (MESA). Proc. IX° Cong. Nazionale Della Soc. Italiana Androl., Ancona, Italy, pp. 159165, 1995.

Articles in General Readership Magazines

1. Hill, GM, M Schiewe, RA Harpel, JP Blanchard, DL Thompson Jr and RA Godke. Dietary flushing and calf separation effects on cow reproductive and calf gain performance. La Livestock Prod Rep 24:142-149, 1983.

2. Hill, GM, M Schiewe, RA Harpel, JP Blanchard, DL Thompson Jr and RA Godke. Does dietary flushing and calf removal improve productive efficiency of beef cows?. La Agricul 27:22-24, 1984.

Abstracts and Posters

1. Looney, CR, SA Voelkel, MC Schiewe, DL Thompson Jr and RA Godke. Comparison of post-collection prostaglandin F2a (PGF2a) treatments for luteolysis in superovulated donor cattle. Theriogenology 17:98, 1982.

2. Schiewe, MC, CR Looney, KG Hill, CA Johnson and RA Godke. Transferrable
embryo recovery rates following different artificial insemination schedules in beef donor cattle. Theriogenology 19:147, 1983. (Intl Student Research, Runner-up)

3. Hill, GM, RA Godke, RA. Harpel, JP Blanchard and M Schiewe. Flushing and
calf separation effects on cow and calf performance. J Anim Sci (Suppl. 1) 57:22, 1983.

4. Hill, KG, CR Looney, MC Schiewe and RA Godke. Effect of different lot
numbers of follicle stimulating hormone (FSH-P) on superovulation response of donor cattle. Theriogenology 21:241, 1984.

5. Schiewe, MC, PM Schmidt, M Bush and DE Wildt. Effect of absorbed/ retained ethylene oxide in plastic culture dishes on embryo development in vitro. Theriogenology 21:260, 1984. (Intl Student Research, Winner)


6. Schiewe, MC, JG Howard, LD Stuart, KL Goodrowe and DE Wildt. Human menopausal gonadotropin (hMG) for superovulation of sheep. Theriogenology 23:227, 1985.

7. Schiewe, MC, SA Voelkel and RA Godke. Artificial insemination (AI) of superovulated beef cattle with a single insemination of frozen semen. Theriogenology 23:228, 1985.

8. Schmidt, PM, MC Schiewe and DE Wildt. Variables influencing post-thaw embryo survival rates in mice. Theriogenology 23:229, 1985. (Intl Student Research, Winner)

9. Schiewe, MC, PM Schmidt, WF Rall and DE Wildt. Influence of cryoprotectant and plunge temperature on post-thaw viability of ovine embryos. Biol Reprod (Suppl. 1) 32:98, 1985.

10. Howard, JG, M Bush, MC Schiewe, V de Vos and DE Wildt. Further developments in comparative semen freezing in free-ranging african elephants. Proc. Am. Assoc. Zoo Vet., pp 31-32, 1985.

11. Schiewe, MC, PM Schmidt and DE Wildt. Toxicity potential of ethylene oxide residues in straw containers used for embryo cryopreservation. Theriogenology 25:194, 1986.

12. Schiewe, MC, M Bush, V de Vos and DE Wildt. Semen characteristics, sperm freezing and endocrine profiles in free-ranging wildebeest and greater kudu. Biol Reprod (Suppl. 1) 36:158, 1987.

13. Pontbriand, D, JG Howard, MC Schiewe, LD Stuart and DE Wildt. Influence of freezing method and cryoprotective diluent on post-thaw survival and acrosomal integrity of ram spermatozoa. Cryobiology 24:584-585, 1987.

14. Schiewe, MC, M Bush, LP Phillips and DE Wildt. Application of embryo techniques to an endangered species: The scimitar-horned oryx. Theriogenology 29:303, 1988.

15. Raphael, BL, NM Loskutoff, JG Howard, BA Wolfe, LA Nemec, MC Schiewe and DC Kraemer. Embryo transfer and artificial insemination in suni (Neotragus moschatus zuluensis). Theriogenology 31:244, 1989.

16. Rall, WF, MC Schiewe, M Bush and DE Wildt. Cryopreservation of oocytes and embryos collected from wildlife species. Cryobiology 26:562-563, 1989.

17. Schiewe, MC, WF Rall, LD Stuart and DE Wildt. In situ straw dilution of ovine embryos cryopreserved by conventional freezing or vitrification. Theriogenology 33:321, 1990.

18. Schiewe, MC, TA Fitz, LD Stuart and JL Brown. Premature luteal regression in superovulated sheep: Relationship to estrous synchronization, circulating hormones, and LH/prostaglandin F2a (PGF) receptors . Biol Reprod (Suppl.) 42:139, 1990.

19. Schiewe, MC, TC Wood and PM Schmidt. The lack of antibody sensitivity by mouse trophectoderm during immunosurgery. Theriogenology 35:268, 1991.

20. Schiewe, MC and SM Seidel. A decade of student research competition. Theriogenology 37:332, 1992.

21. Schiewe, MC, CT Hansen and PM Schmidt. Comparative production and viability of zona pellucida-enclosed murine trophectodermal vesicles. Theriogenology 37:292, 1992.

22. Monfort, SL, GW Asher, WF Rall, TC Wood, MC Schiewe, LR Williamson and
M Bush. Successful intrauterine insemination in Eld's deer (Cervus eldi thamin) using frozen-thawed spermatozoa. Biol Reprod (Suppl. 1) 46: 97, 1992.

23. Rojas, FJ, C Garner, M Schiewe, RH Asch, JP Balmaceda and I Moretti-Rojas. Enzymatic amplification of Y-chromosome specific human blastomeres: Evaluation of a simplified method for use in preimplantation genetic diagnosis of X-linked diseases. Proc. 41st Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), pg. A2 (No. O-004), 1993.

24. Tadir, Y, MC Schiewe, Y Neev, P Ho, T Ord, JP Balmaceda, RH Asch and MW
Berns. Spontaneous and Induced zona pellucida hardness: Measurements using enzyme assay and a non-contact laser micromanipulation. Proc. 41st Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), pg. A9 (No. O-021), 1993.

25. Schiewe, MC, E Araujo Jr, RH Asch and JP Balmaceda. Enzymatic characterization of zona pellucida hardening in human eggs and embryos. Proc. 49th Ann Amer Fertil Soc Mtg (Abstr.O-103), Suppl.:S49, 1993.

26. Schiewe, M.C., N.M. Loskutoff, B.S. Durrant, L.A. Johnston, D.L. Armstrong and L.G. Simmons. Gaur sperm cryopreservation trail: Analysis of packaging type and rapid freezing method for potential field application. Theriogenology 41: 291, 1994.

27. Schiewe, M.C., N.L. Hazeleger, P. Gonzales-Suau and J.P. Balmaceda. Characterizing the mouse blastocyst anti-hatching model: Influence of initial developmental stage and late serum supplementation. Proc. 42nd Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), pg. A11 (No. O-022), 1994.

28. Schiewe, M.C., N.L. Hazeleger, C. Sclimenti and J.P. Balmaceda. Characterizing the mouse blastocyst anti-hatching model: Abnormal zona hardness and physical expansion are not the cause of hatching inhibition. Proc. 50th Ann. Am. Fertil. Soc. Mtg., Fertil Steril (Abstr. P-285), Suppl.:S218, 1994.

29. Schiewe, MC, Y Neev, N Hazeleger, Y Tadir, MW Berrns and J Balmaceda.
Developmental competence of mouse embryos folowing zona drilling using a non-contact Ho:YSSG laser system. Theriogenology 43: 315, 1995.

30. Schiewe, MC, RH Asch, JL Frederick, S Stone and JP Balmaceda. Factors influencing the efficacy of intracytoplasmic sperm injection (ICSI). Proc. World Congr. IVF, Vienna, Austria, 1995.

31. Gook, D, SM Osborn, MC Schiewe, RPS Jansen, RH Asch and WIH Johnston. Embryo development of cryopreserved human oocytes. Proc. World Congr. IVF, Vienna, Austria, 1995.

32. Schiewe, MC, RH Asch, JL Frederick, T Ord, E Marello and JP Balmaceda. Efficacy of intracytoplasmic sperm injection (ICSI) is independent of the male factor/infertility problem. Proc. 43rd Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), 1995.

33. Schiewe, MC, GE Ringler, AL Stein, JM Varygas, M Scrooc, J Greene and RP Marrs. High fertilization, cleavage and pregnancy rates using a simplified intracytoplasmic sperm injection (ICSI) procedure in human infertility treatment. Theriogenology 43: 303, 1996.

34. Ortensi, A, M Amodei, C Barbieri, G. Custo, P Giovenco, V Marchese, A Massacesi, M Schiewe, A Viega, E Santuari and RH Asch. Pregnancy obtained by ICSI utilizing epididymal spermatozoa - case report. Proc. II° Cong. Nazionale Della Soc. Italiana Androl. Med. (SIAM), Firenze, Italy, 1996.

35. Schiewe, MC, B Stone, M Scrooc, JM Vargyas and RP Marrs. Use of ICSI for patients following a failed sperm penetration assay (SPA). Proc. 44th Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), 1996.

36. Schiewe, MC, AL Stein, J Greene, GE Ringler and RP Marrs. Selective assisted hatching is beneficial but not mandatory for ICSI-derived embryos. Proc. 44th Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), 1996.

37. Schiewe, MC, A Massacesi, C Barbieri, E Santuari, P Santuari, RP Marrs. Patient stimulation response and egg quality can adversely influence ICSI outcomes. Proc. Inter. Conf. ICSI: Serono Symp., Thessaloniki, Greece, Sept. 20-21, 1996.

38. Massacesi, A, M Amodei, P Giovenco, A Ortensi, V Marchese, K Ierardi, MC Schiewe. Improved ICSI results in six consecutive series in Rome, Italy. Proc. Inter. Conf. ICSI: Serono Symp., Thessaloniki, Greece, Sept. 20-21, 1996.


39. Barbieri, C, MC Schiewe, P Santuari, RP Marrs.Successful treatment of cleavage failure in two ICSI patients. Proc. Inter. Conf. ICSI: Serono Symp., Thessaloniki, Greece, Sept. 20-21, 1996

40. Schiewe, MC, M Scrooc, J Greene, RP Marrs. ICSI outcomes are influenced by egg factor conditions. Proc. 52nd Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl), pg. S39, 1996.

41. Schiewe, MC, A Dean. ICSI pipette design: spike versus no spike? Proc. 52nd Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl), pg. S255, 1996.

42. Schiewe, MC, A Massacesi, K Ierardi, M Amodei, C Barbieri, P Giovenco, E Santuari, P Santuari, RP Marrs. 1997. BRL cell coculture and assisted hatching of ICSI-derived human zygotes. Theriogenology 47: 252.

43. Schiewe, MC. Production and use of zona pellucida-intact mouse trophectodermal vesicles for placental donation. Proc. 45th Ann. Pacific Coast Fertil. Soc. Mtg., Fertil Steril (Suppl.), O-13, pg. 6, 1997.

44. Schiewe, MC, A Massacesi, K Ierardi, M Amodei, C Barbieri, E Santuari, RP Marrs. Egg quality and ICSI outcomes are influenced by patient response to controlled ovarian hyperstimulation. Proc. Serono Symposium: Human Oocyte: From Physiology to IVF, Bologna, Italy, Pg. 99, April 1997.

45. Marrs, RP and MC Schiewe. Egg quality influences ICSI outcomes. Proc. Serono Symposium: Human Oocyte: From Physiology to IVF, Bologna, Italy, April 1997.

46. Schiewe, MC, A Massacesi, E Santuari, M Amodei, C Barbieri, K Ierardi, RP Marrs. Comparative development of ICSI-derived Human embryos in glucose-free, phosphate-free simple media solutions. ESREA conference, Hum. Reprod. (Suppl.) R-145, pg. 298, 1997.

47. Schiewe, MC, GE Ringler, CJ Bennett, CM Rothman, RP Marrs. Cryopreservation of Intact Testis Biopsies for ICSI. Proc. 53rd Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl), pg. S115, 1997.

48. Shiina, Y, BA Stone, GM Hubbard, MC Schiewe, RP Marrs. Levels of sex-hormone binding globulin (SHBG) in follicular fluids (FF) and in serum of patients undergoing controlled ovarian hyperstimulation (COH). Proc. 53rd Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl), pg. S202, 1997.

49. Schiewe, MC, GE Ringler, AL Stein, RP Marrs. Influence of Fertinex™ on oocyte physiology and ICSI/IVF outcomes. Proc. 53rd Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl), pg. S222, 1997.

50. Schiewe, MC. Experimental aspects of assisted fertilization. Proc. Serono Symposium: ART: State of the Art, Maui, HA, pg. 15, 1997.

51. Schiewe, MC, A Massacesi, E Santuari, M Amodei, C Barbieri, P Giovenco, RP Marrs. Comparative development of ICSI-derived human embryos in HTF, P-1, QB-XI and D3 media solutions. Proc. Serono Symposium: ART: State of the Art, Maui, HA, pg. 47,
1997.

52. Schiewe, MC, J Conia, Y Tadir, RP Marrs. Laser assisted hatching using a 1480nm diode laser in a computer controlled non-contact mode: mouse model. Proc. 46th Ann Pacif. Coast Fertil. Soc. Mtg. (P-16), Fertil. Steril. 69:595, 1998.

53. Schiewe, MC, E Santuari, M Amodei, C Barbieri, P Giovenco, A Massacesi, K Ierardi, RP Marrs. Improved ICSI-ET success using a Cook Soft-Pass™ catheter. Proc. 46th Ann
Pacif. Coast Fertil. Soc. Mtg. (P-17), Fertil. Steril. 69:595, 1998.

54. Schiewe, MC, GE Ringler, Al Stein, M Scrooc, J Greene, RP Marrs. Analysis of ICSI and IVF Outcomes in stimulation cycles using Fertinex™ alone or in combination with Pergonal™ or Metrodin™. Proc. 46th Ann Pacif. Coast Fertil. Soc. Mtg. (P-18), Fertil. Steril.69:596, 1998.

55. Schiewe, MC, GE Ringler, CJ Bennett, V Marchese, E Santuari, RP Marrs. Effectiveness of semen procurement method and spermatogenic cell type for ICSI of azoospermic and severe oligoasthenospermic men. Proc. 46th Ann Pacif. Coast Fertil. Soc. Mtg. (P-19), Fertil. Steril. 69:595, 1998.

56. Bennett, CJ, SI Zeitlin, ME Robinson, MC Schiewe. Effectiveness of incisional vs. Tru- cut™ testes biopsy for sperm isolation and intracytoplasmic sperm injection (ICSI). Proc. 54th Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl. 1), 70: S268 (P-453) 1998.

57. Zeitlin, SI, MC Schiewe, ME Robinson, GE Ringler, AL Stein, RP Marrs, J Rafer, CJ Bennett. The acheivement of pregnancies using intracytoplasmic sperm injection in anejaculatory men. Proc. 54th Ann. Amer. Soc. Reprod. Med. Mtg./IFFS, Fertil Steril (Suppl. 1), 70: S268 (P-454) 1998.

58. Massacesi, A, P Santuari, M Amodei, C Barbieri, P Giovenco, RP Marrs, MC Schiewe. Comparative development of ICSI-derived human embryos in HTF, P-1, QB-XI and D3 media solutions. Proc. 54th Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl. 1), 70: S94 (PO-253) 1998.

59. Schiewe, MC, Y Han, M Scrooc, RP Marrs. Murine embryo growth in different culture media and sequential combinations: A model for application to human IVF. Proc. 47th Ann Pacif. Coast Reprod. Soc. Mtg. (O-11), Fertil. Steril. 71(Suppl.1):10S, 1999.

60. Schiewe, MC, Y Han, RP Marrs. Single sperm freezing in evacuated mouse zona pellucida: Comparative trial on zona preparation and sperm isolation procedures. Proc. 47th Ann Pacif. Coast Reprod. Soc. Mtg. (O-3), Fertil. Steril. 71(Suppl.1):7S, 1999.

61. Schiewe, MC, GE Ringler, RP Marrs, AL Stein, JM Varygas, J Greene. Increased embryo transfer pregnancy rates using assisted hatching on Day 3 frozen-thawed embryos. Proc. 47th Ann Pacif. Coast Reprod. Soc. Mtg. (P-15), Fertil. Steril. 71(Suppl.1):17S, 1999.

62. Schiewe, MC and RP Marrs. Developmental competence of mouse blastocysts grown in different culture media and sequential combinations. Proc 2nd ALPHA Conference (Copenhagen, Sept. 16-19), P6, 1999.

63. Ringler, GE, RP Marrs, AL Stein, JM Varygas. J Greene, MC Schiewe. Improved pregnancy rates using assisted hatching on Day 3 frozen-thawed embryos. Proc. 55th Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl. 1), 72:S86, 1999. 64. Schiewe, MC, GD Hubert and RP Buyalos. IVF-ICSI pregnancy outcomes in a randomized embryo transfer catheter trial comparing the Cook soft-pass catheter to the Edward-Wallace catheter. Proc. 57th Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl. 1), 76:S181, 2001.

65. Schiewe, MC, GD Hubert and RP Buyalos. Human zygote cryopreservation using CBS cryobiostraws: A randomized clinical study. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl. 3), 77:S22, 2002.

66. Schiewe, MC, GD Hubert and RP Buyalos. Testicular tissue processing: Maximizing viability for cryopreservation and clinical use. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3), 81:S15; O-13, 2004.

67. Schiewe, MC, GD Hubert and RP Buyalos. Poor fertility predictive value of the sperm chromatin structure assay (SCSA) is neutralized by sperm injection: Case studies. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3), 81:S27-27; P-32, 2004.

68. Schiewe, MC, GD Hubert and RP Buyalos. Use of CBSTM high security straws for conventional freezing of human blastocysts. Proc. Ann. Pacific Coast Reprod. Soc. Mtg., Fertil Steril (Suppl 3); P-58, 2005.

69. Schiewe, MC, GD Hubert and RP Buyalos. Pre-freeze manual collapsing of the blastocoel cavity increases cryosurvival of human blastocysts. Proc. 61st Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl 1), 84:S182, 2005.

70. Schiewe, MC, GD Hubert and RP Buyalos. Comparative echogenicity of various soft-tipped embryo transfer catheters . Proc. 61st Ann. Amer. Soc. Reprod. Med. Mtg., Fertil Steril (Suppl 1), 84:S349-350, 2005.

 

** Bolded numbers highlight pioneering research studies that have had significant research, industry or clinical effects.


Other Types of Publications

1. Ph.D. Dissertation (1989):
"Comparative studies of estrous synchronization, ovulation induction, luteal function and embryo cryopreservation in domestic sheep and application to related investigations of nondomestic ungulate species"

2. M.S. Thesis (1983):
"Various artificial insemination schedules and fertility of superovulated beef donor cattle"